Building Ribosomes from Computational LEGO

Title

Building Ribosomes from Computational LEGO

Subject

Semi-finalist in the Graduate Image of Research Contest 2016.
Honorable Mention in the Graduate Image of Research Contest 2016.

Description

Ribosomes, the molecular machines responsible for assembling protein from amino acids, are among the most fundamental structures in biology and are found across all domains of life. These machines are assembled hierarchically by the association of 54 proteins to three strands of RNA (in bacteria) in a highly coordinated sequence. My research involves the construction of a lattice based, computational model of Escherichia coli to study the in vivo assembly of the ribosomal small subunit. Explicit in this model is the transcription and translation of the ribosomal components. The central cell in this figure is a visualization of a single time point in the simulation. The cubes show how the simulation domain is discretized
onto a lattice. The spheres represent the ribosomal protein (gray), small (yellow) and large (brown) subunits, completed ribosomes (white), and assembling ribosomes (orange). Inside the cell is a representation of the bacterial chromosome from which the ribosomal constituents are transcribed. This structure is from a separate project of mine which aims to provide accurate gene positioning for my whole cell simulations. These projects lay the
groundwork for more complete models of living cells.

Creator

Tyler Earnest

Date

2016

Rights

Copyright 2016 Tyler Earnest

Relation

Physics

Original Format

tiff

Files

Earnest_Tyler.tiff

Citation

Tyler Earnest, “Building Ribosomes from Computational LEGO,” Image of Research: Celebrating Student Research at Illinois, accessed November 20, 2017, http://imageofresearch.omeka.net/items/show/216.